# PRRT2 Patient Profile — Nav Channel & Symptom Map

**One adult PRRT2 patient's full symptom constellation mapped to the underlying circuit mechanisms — from Nav channel biology through basal ganglia dysfunction to each specific presentation.**

{% hint style="warning" %}
**🧭 Foundation Note**

*This diagram maps a real PRRT2 patient's experience — confirmed pathogenic variant, diagnosed in adulthood after decades without answers. Symptom-to-circuit mappings are grounded in published science. The management approach in Section 7 is illustrative — one patient's supervised medical picture, not a recommendation or protocol to follow. Nothing here is medical advice.*
{% endhint %}

This diagram was built to answer a question most PRRT2 patients never get answered clearly: *why* does this gene produce this particular combination of symptoms in this particular person? The circuit-level explanation — following the chain from Nav channel instability through basal ganglia misfiring to each named presentation — is both scientifically grounded and, for many patients, the first coherent account of their own neurology they have ever seen.

{% embed url="<https://prrt2.github.io/expressions/diagrams/my_prrt2_diagram.html>" %}

See [Exploring the Wider Spectrum](https://www.prrt2.org/exploring-the-wider-spectrum) for the referenced version of the atypical presentations covered here.


---

# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://www.prrt2.org/expressions/visuals-and-diagrams/my-prrt2-symptom-map.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.